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Alcohol and breast cancer in women: a pooled analysis of cohort studies. SA Smith-Warner Epidemiologic evidence for beta-carotene and cancer prevention. The effect of beta-carotene on the mortality of male smokers is modified by smoking and by vitamins C and E:evidence against a uniform effect of nutrient av T Woodhill — 13 The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Alpha-Tocopherol and beta-carotene supplements and lung cancer Ingår i Cancer Epidemiology, Biomarkers and Prevention, s. Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia Beta-carotene intake and risk of postmenopausal breast cancer. av PO Darnerud · Citerat av 2 — The conclusions regarding red meat and cancer in the WCRF 2007 Report are mainly based on 17 cohort studies (Tables 2a,b). Of these, 11 are studies from retinol equivalents; 1 retinol equivalent (re) = 1 µg retinol = 12 µg β-carotene.
Tuberculosis may increase lung cancer risk through substantial and prolonged pulmonary inflammation. However, prospective data on tuberculosis and lung cancer risk are limited. Methods: Our study included 29,133 Finnish male smokers followed prospectively in the Alpha-Tocopherol, Beta-Carotene Cancer (Alpha-Tocopherol, Beta-Carotene Cancer Prevention trial [ATBC]) 29,133 male smokers* aged 50–69 y, Finland Beta-carotene administered as 20 mg daily or vitamin E administered as 50 mg daily 6.1 Increased (P 5.04) Hennekens, 199610 (Physician’s Health Study) 22,071 male physicians aged 40–84 y, U.S. Beta-carotene administered as 50 mg on The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. View abstract. Beta carotene and cancer: risk or protection?
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The prospective data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study (ATBC study) were used to examine the relationship between the consumption of total meat and specific types of meats (red meat, processed meat and poultry) and the risk of type 2 diabetes in Finnish middle-aged male smokers. Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study conducted in southwestern Finland has been an integral cohort research resource for NCI for nearly three decades.
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The ATBC Study is uniquely positioned to investigate the relationship between mtDNA copy number and pancreatic cancer risk because of the population’s exposure to oxidative stress due to smoking, their exposure to the beta-carotene and alpha-tocopherol study intervention, and the collection of biomarkers (beta-carotene, alpha-tocopherol, and retinol measured at baseline and after the study intervention), all … 2018-06-08 Beta-carotene levels were almost 50 per cent higher in women without cancer than in the ones who developed breast cancer.
Further, cigarettes with higher tar and nicotine content are associated with a higher risk of lung cancer. The effect of beta‐carotene supplementation on cancer incidence has been investigated in several randomized controlled trials.
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The beneficial association supported by overwhelming observational epidemiologic data was abruptly challenged by the results of a few controlled trials of β-carotene suppleme… Beta-carotene and lung cancer: a case study. The conflicting evidence of the relation between beta-carotene and lung cancer in humans serves as a poignant case study with respect to what types of evidence are sufficient to support or change a nutrition recommendation. This article is a review of the available evidence of the relation between b …. Introduction: The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study demonstrated that β-carotene supplementation increases lung cancer incidence in smokers. Further, cigarettes with higher tar and nicotine content are associated with a higher risk of lung cancer. A number of epidemiological studies have reported associations of beta-carotene plasma levels or intake with decreased lung cancer risk. However, intervention studies in smokers have unexpectedly reported increased lung tumor rates after high, long-term, beta-carotene supplementation.
However, intervention studies in smokers have unexpectedly reported increased lung tumor rates after high, long-term, beta-carotene supplementation. Our study found little indication that increased intake of vitamin A or beta-carotene from the diet or supplements protects against the development of cancer overall. Dietary vitamin A intake was highly associated with smoking status; 25% of current smokers were in the highest third of dietary vitamin A consumption versus 32% of past smokers and 36% of never-smokers. 2017-09-20
The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study was a randomized, double-blind, placebo-controlled primary-prevention trial undertaken to determine whether supplementation with alpha
A randomized, placebo-controlled clinical trial of beta-carotene and retinol was conducted with 755 former asbestos workers as study subjects. The targeted endpoint for the intervention study was a reduction in the incidence and prevalence of sputum atypia. The dosage of …
The harmful effect of beta‐carotene in smokers might also concern other cancer sites, as recently suggested by the results of the EPIC cohort study showing an increased risk of colorectal cancer associated to fruit and vegetable consumption in smokers.
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the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst, 1996. 88(21): p. 1550-.
Thus, within this one study both the expected beneficial relation between dietary and serum β-carotene status and lung cancer risk and the apparently adverse effect of active supplementation with 20 mg/d were observed. This case study of beta-carotene and lung cancer stresses the importance of having results from at least one, and preferably more, large, randomized intervention trial before public health recommendations concerning micronutrient supplementation are considered. Background: Epidemiologic evidence indicates that diets high in carotenoid-rich fruits and vegetables, as well as high serum levels of vitamin E (alpha-tocopherol) and beta carotene, are associated with a reduced risk of lung cancer. Methods: We performed a randomized, double-blind, placebo-controlled primary-prevention trial to determine whether daily supplementation with alpha-tocopherol, beta carotene, or both would reduce the incidence of lung cancer and other cancers.
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33 Several mechanisms might be involved according to in vitro studies conducted in various cell lines: beta‐carotene may act as a Trial name, country (reference) Intervention Study subjects Results; Linxian General Population Nutrition Intervention Trial, China (6, 7)15 milligrams (mg) beta-carotene, 30 mg alpha-tocopherol, and 50 micrograms (µg) selenium daily for 5 years Healthy men and women at increased risk of developing esophageal cancer and gastric cancer Abstract. In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for age, smoking history and duration of storage of the serum samples.